University of California, San Diego Leichtag Room 283 9500 Gilman Drive, 0721 La Jolla, CA 92093-0721   Email :   Phone :  (858) 822-4007  Fax :  (858) 822-5888

University of California, San Diego
Leichtag Room 283
9500 Gilman Drive, 0721
La Jolla, CA 92093-0721

Email :
Phone : (858) 822-4007
Fax : (858) 822-5888


A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. Sanyal A, Chen AJ, Nakayasu ES, Lazar CS, Zbornik EA, Worby CA, Koller A, Mattoo S. J Biol Chem. 2015 Mar 27;290(13):8482-99. doi: 10.1074/jbc.M114.618348. Epub 2015 Jan 19. PMID: 25601083

Unpacking the unfolded protein response. Worby CA, Dixon JE. Cell. 2014 Sep 11;158(6):1221-4. doi: 10.1016/j.cell.2014.08.025. PMID: 25215479

A secreted tyrosine kinase acts in the extracellular environment. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Cell. 2014 Aug 28;158(5):1033-44. doi: 10.1016/j.cell.2014.06.048. PMID: 25171405

PTEN. Worby CA, Dixon JE. Annu Rev Biochem. 2014;83:641-69. [PMID: 24905788][4]

Identification of a Mammalian-type Phosphatidylglycerophosphate Phosphatase in the Eubacterium Rhodopirellula baltica. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. J Biol Chem. 2013 Feb 15;288(7):5176-85. PMID: 23293031

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. Science. 2012 Jun 1;336(6085):1150-3. PMID: 22582013

Comparative analysis of Histophilus somni IbpA with other FIC enzymes reveals differences in substrate and nucleotide specificities. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. J Biol Chem. 2011 Jul 27. PMID: 21795713

Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Cell Metabolism. 2011 Jun 8;13(6):690-700. PMID: 21641550

Glycogen synthase: an old enzyme with a new trick. Worby CA, Dixon JE. Cell Metabolism. 2011 Mar 2;13(3):233-4. PMID: 21356510

Structural basis of Fic-mediated adenylylation. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE. Nat Struct Mol Biol. 2010 Aug;17(8):1004-10. PMID: 20622875

Lafora disease: insights into neurodegeneration from plant metabolism. Gentry MS, Dixon JE, Worby CA. Trends Biochem Sci. 2009 Dec;34(12):628-39. PMID: 19818631

The fic domain: regulation of cell signaling by adenylylation. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. Mol Cell. 2009 Apr 10;34(1):93-103. PMID:19362538. Authors contributed equally to this work.

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7970-5. PMID: 18524949

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). Worby CA, Gentry MS, Dixon JE. J Biol Chem 2008 Feb 15;283(7):4069-76. PMID: 18070875