University of California, San Diego Leichtag Room 283 9500 Gilman Drive, 0721 La Jolla, CA 92093-0721   Email :   Phone :  (858) 822-0684  Fax :  (858) 822-5888

University of California, San Diego
Leichtag Room 283
9500 Gilman Drive, 0721
La Jolla, CA 92093-0721

Email :
Phone : (858) 822-0684
Fax : (858) 822-5888


A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. Pollak AJ, Liu C, Gudlur A, Mayfield JE, Dalton ND, Gu Y, Chen J, Heller Brown J, Hogan PG, Wiley SE, Peterson KL, Dixon JE. Elife. 2018 Dec 6;7. pii: e41378. doi: 10.7554/eLife.41378. PMID: 30520731

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase. Banerjee S, Ji C, Mayfield JE, Goel A, Xiao J, Dixon JE, Guo X. 2.PNAS July 9, 2018. 201806797.

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain. Portz B, Lu F, Gibbs EB, Mayfield JE, Rachel Mehaffey M, Zhang YJ, Brodbelt JS, Showalter SA, Gilmour DS. Nat Commun. 2017 May 12;8:15231. doi: 10.1038/ncomms15231. PubMed PMID: 28497792; PubMed Central PMCID: PMC5437306.

Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry. Mayfield JE, Robinson MR, Cotham VC, Irani S, Matthews WL, Ram A, Gilmour DS, Cannon JR, Zhang YJ, Brodbelt JS. ACS Chem Biol. 2017 Jan 20;12(1):153-162. doi: 10.1021/acschembio.6b00729. Epub 2016 Dec 1. PubMed PMID: 28103682; PubMed Central PMCID: PMC5376213.

Dephosphorylating eukaryotic RNA polymerase II. Mayfield JE, Burkholder NT, Zhang YJ. Biochim Biophys Acta. 2016 Apr;1864(4):372-87. doi: 10.1016/j.bbapap.2016.01.007. Epub 2016 Jan 15. Review. PubMed PMID: 26779935; PubMed Central PMCID: PMC4761483.

Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase. Irani S, Yogesha SD, Mayfield JE, Zhang M, Zhang Y, Matthews WL, Nie G, Prescott NA, Zhang YJ. Sci Signal. 2016 Mar 1;9(417):ra24. doi: 10.1126/scisignal.aad4805. PubMed PMID: 26933063; PubMed Central PMCID: PMC4801511.

Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Mayfield JE, Fan S, Wei S, Zhang M, Li B, Ellington AD, Etzkorn FA, Zhang YJ. ACS Chem Biol. 2015 Oct 16;10(10):2405-14. doi: 10.1021/acschembio.5b00296. Epub 2015 Sep 15. PubMed PMID: 26332362; PubMed Central PMCID: PMC4788383.

Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II. Yogesha SD, Mayfield JE, Zhang Y. Molecules. 2014 Jan 27;19(2):1481-511. doi: 10.3390/molecules19021481. Review. PubMed PMID: 24473209; PubMed Central PMCID: PMC4350670.

Viewing serine/threonine protein phosphatases through the eyes of drug designers. Zhang M, Yogesha SD, Mayfield JE, Gill GN, Zhang Y. FEBS J. 2013 Oct;280(19):4739-60. doi: 10.1111/febs.12481. Epub 2013 Sep 5. Review. PubMed PMID: 23937612; PubMed Central PMCID: PMC4349438.

Neuronal expression of the ubiquitin E3 ligase APC/C-Cdh1 during development is required for long-term potentiation, behavioral flexibility, and extinction. Pick JE, Wang L, Mayfield JE, Klann E. Neurobiol Learn Mem. 2013 Feb;100:25-31. doi: 10.1016/j.nlm.2012.11.005. Epub 2012 Dec 10. PubMed PMID: 23238556; PubMed Central PMCID: PMC3562375.