University of California, San Diego Leichtag Room 283 9500 Gilman Drive, 0721 La Jolla, CA 92093-0721   Email :   Phone :  (858) 822-0684  Fax :  (858) 822-5888

University of California, San Diego
Leichtag Room 283
9500 Gilman Drive, 0721
La Jolla, CA 92093-0721

Email :
Phone : (858) 822-0684
Fax : (858) 822-5888


1: Banerjee S, Ji C, Mayfield JE, Goel A, Xiao J, Dixon JE, Guo X. Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.PNAS July 9, 2018. 201806797.

2: Portz B, Lu F, Gibbs EB, Mayfield JE, Rachel Mehaffey M, Zhang YJ, Brodbelt JS, Showalter SA, Gilmour DS. Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain. Nat Commun. 2017 May 12;8:15231. doi: 10.1038/ncomms15231. PubMed PMID: 28497792; PubMed Central PMCID: PMC5437306.

3: Mayfield JE, Robinson MR, Cotham VC, Irani S, Matthews WL, Ram A, Gilmour DS, Cannon JR, Zhang YJ, Brodbelt JS. Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry. ACS Chem Biol. 2017 Jan 20;12(1):153-162. doi: 10.1021/acschembio.6b00729. Epub 2016 Dec 1. PubMed PMID: 28103682; PubMed Central PMCID: PMC5376213.

4: Mayfield JE, Burkholder NT, Zhang YJ. Dephosphorylating eukaryotic RNA polymerase II. Biochim Biophys Acta. 2016 Apr;1864(4):372-87. doi: 10.1016/j.bbapap.2016.01.007. Epub 2016 Jan 15. Review. PubMed PMID: 26779935; PubMed Central PMCID: PMC4761483.

5: Irani S, Yogesha SD, Mayfield J, Zhang M, Zhang Y, Matthews WL, Nie G, Prescott NA, Zhang YJ. Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase. Sci Signal. 2016 Mar 1;9(417):ra24. doi: 10.1126/scisignal.aad4805. PubMed PMID: 26933063; PubMed Central PMCID: PMC4801511.

6: Mayfield JE, Fan S, Wei S, Zhang M, Li B, Ellington AD, Etzkorn FA, Zhang YJ. Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. ACS Chem Biol. 2015 Oct 16;10(10):2405-14. doi: 10.1021/acschembio.5b00296. Epub 2015 Sep 15. PubMed PMID: 26332362; PubMed Central PMCID: PMC4788383.

7: Yogesha SD, Mayfield JE, Zhang Y. Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II. Molecules. 2014 Jan 27;19(2):1481-511. doi: 10.3390/molecules19021481. Review. PubMed PMID: 24473209; PubMed Central PMCID: PMC4350670.

8: Zhang M, Yogesha SD, Mayfield JE, Gill GN, Zhang Y. Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS J. 2013 Oct;280(19):4739-60. doi: 10.1111/febs.12481. Epub 2013 Sep 5. Review. PubMed PMID: 23937612; PubMed Central PMCID: PMC4349438.

9: Pick JE, Wang L, Mayfield JE, Klann E. Neuronal expression of the ubiquitin E3 ligase APC/C-Cdh1 during development is required for long-term potentiation, behavioral flexibility, and extinction. Neurobiol Learn Mem. 2013 Feb;100:25-31. doi: 10.1016/j.nlm.2012.11.005. Epub 2012 Dec 10. PubMed PMID: 23238556; PubMed Central PMCID: PMC3562375.