Fam20C transcends the boundaries of biomineralization

Sandy, Cell and sandwich

Sandy, Cell and sandwich

Fam20C, the original casein kinase was known to play a major role in biomineralization and Raine's syndrome. However, recent work by Vincent Tagliabracci and Sandy Wiley has shown that Fam20C exhibits roles far beyond biomineralization and is responsible in generating more than 90% of the secreted phosphoproteome. Fam20C has been shown to play diverse roles in various biological processes including proper adhesion and invasion of breast cancer cells. The paper has been published in Cell. Jack was specially proud and congratulated everyone involved with the work. The work was a result of a major collaboration between Jack's lab and laboratories in UT Southwestern and University of Wisconsin Madison. Sandy Wiley was in an especially jovial mood and was found printing unlimited copies of the paper and pinning them all around the floor. During lunch she was seen working on a bowl of salad and tofu sandwich and holding on to a copy of the paper. "Vinnie and I are both thrilled that our recent Fam20C story finally came out in Cell today!  It has been a long road, and we are indebted to our wonderful collaborators who pitched in to make this study come together. I am sure that Vinnie is also feeling rather relieved because he was supposed to pay the bar bill when we went out to celebrate the paper coming out in print.  Honestly, I suspect he timed his move to Texas to conveniently get out of paying.  We were planning to go to Rappongi.  It is pretty pricey.  I guess I can’t blame him, really." Vincent Tagliabracci was also in an ecstatic mood ,"Sandy is da BOMB!!" He further added, "Thats a lot of substrates!.......Dude, its not secreted!!" It is clear that Vinnie is too 'happy' to provide sober comments at the moment but we all congratulate him and miss him anyway. Kim Nguyen who coauthored the work also had a rare grin on her face the whole day. Jixin Cui, another coauthor, was happy and bright as always. For more details please refer to  UCSD press release and Cell.