University of California, San Diego
Leichtag Room 283
9500 Gilman Drive, 0721
La Jolla, CA 92093-0721

Email : sawiley@ucsd.edu
Phone : (858) 822-0684
Fax : (858) 822-5888

Publications

Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide. Qiu Y, Poppleton E, Mekkat A, Yu H, Banerjee S, Wiley SE, Dixon JE, Kaplan DL, Lin YS, Brodsky B. Biophys J. 2018 Dec 18;115(12):2327-2335. doi: 10.1016/j.bpj.2018.11.012. Epub 2018 Nov 16. PMID: 30527445

A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. Pollak AJ, Liu C, Gudlur A, Mayfield JE, Dalton ND, Gu Y, Chen J, Heller Brown J, Hogan PG, Wiley SE, Peterson KL, Dixon JE. Elife. 2018 Dec 6;7. pii: e41378. doi: 10.7554/eLife.41378. PMID: 30520731

Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias EG. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9098-9103. doi: 10.1073/pnas.1706441114. Epub 2017 Aug 7. PMID: 28784772

A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE. Cell. 2015 Volume 161, Issue 7, p1619–1632. PMID: 26091039

Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN (2014) Int J Cardiol. 175(2):297-306. PMID: 24908200

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Appaiah HN, Koller A, Nizet V, White KE, Dixon JE (2014) Proc. Natl. Acad. Sci. U S A., 111(15):5520-5. PMID: 24706917

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. EMBO Mol Med. 2013 Jun;5(6):904-18. PMID: 23703906

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR1, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. PLoS One. 2013 May 15;8(5):e61551. PMID: 23690925

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA, Henry RR, McDonald WG, Colca JR, Simon MI, Ciaraldi TP, Murphy AN. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5422-7. PMID: 23513224

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. Science. 2012 Jun 1;336(6085):1150-3. PMID: 22582013

Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Cell Metab. 2011 Jun 8;13(6):690-700. PMID: 21641550

The novel 2Fe-2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain. Conlan AR, Paddock ML, Axelrod HL, Cohen AE, Abresch EC, Wiley SE, Roy M, Nechushtai R, Jennings PA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):654-9. PMID: 19574633

Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET. Wiley SE, Rardin MJ, Dixon JE. Methods Enzymol. 2009;456:233-46. PMID: 19348892

Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. J Biol Chem. 2008 May 30;283(22):15440-50. PMID: 18385140

MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7. PMID: 17766440

A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr, Dixon JE. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6596-601. PMID: 17420445

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. J Biol Chem. 2007 Aug 17;282(33):23745-9. PMID: 17584744

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5318-23. PMID: 17376863

Excitotoxic injury to mitochondria isolated from cultured neurons. Kushnareva YE, Wiley SE, Ward MW, Andreyev AY, Murphy AN. J Biol Chem. 2005 Aug 12;280(32):28894-902. PMID: 15932874

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Mol Cell. 2005 Jul 22;19(2):197-207. PMID: 16039589

Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network. Copp J, Wiley S, Ward MW, van der Geer P. Am J Physiol Cell Physiol. 2005 Feb;288(2):C403-15. PMID: 15456696

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Dykens JA, Carroll AK, Wiley S, Covey DF, Cai ZY, Zhao L, Wen R. Biochem Pharmacol. 2004 Nov 15;68(10):1971-84. PMID: 15476668

Characterization of the human heart mitochondrial proteome. Taylor SW, Fahy E, Zhang B, Glenn GM, Warnock DE, Wiley S, Murphy AN, Gaucher SP, Capaldi RA, Gibson BW, Ghosh SS. Nat Biotechnol. 2003 Mar;21(3):281-6. PMID: 12592411

Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site. van der Geer P, Wiley S, Pawson T. Oncogene. 1999 May 20;18(20):3071-5. PMID: 10340378

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Li SC, Songyang Z, Vincent SJ, Zwahlen C, Wiley S, Cantley L, Kay LE, Forman-Kay J, Pawson T. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7204-9. PMID: 9207069

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. van der Geer P, Wiley S, Gish GD, Pawson T. Curr Biol. 1996 Nov 1;6(11):1435-44. PMID: 8939605

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. van der Geer P, Wiley S, Gish GD, Lai VK, Stephens R, White MF, Kaplan D, Pawson T. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):963-8. PMID: 8577769

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T. Curr Biol. 1995 Apr 1;5(4):404-12. PMID: 7542991

D-alanine metabolism in the lucinid clam Lucinoma aequizonata. Wiley S, Felbeck H. J. Comp. Physiol. b-Biochemical Systemic and Environmental Physiology, 164:561-569. Article.

Rat T cell response to superantigens. I. V beta-restricted clonal deletion of rat T cells differentiating in rat-->mouse chimeras. Surh CD, Gold DP, Wiley S, Wilson DB, Sprent J. J Exp Med. 1994 Jan 1;179(1):57-62. PMID: 8270883

Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor V beta expression predominates in spinal cord infiltrating T cells. Gold DP, Vainiene M, Celnik B, Wiley S, Gibbs C, Hashim GA, Vandenbark AA, Offner H. J Immunol. 1992 Mar 15;148(6):1712-7. PMID: 1371786

Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. Gold DP, Offner H, Sun D, Wiley S, Vandenbark AA, Wilson DB. J Exp Med. 1991 Dec 1;174(6):1467-76. PMID: 1836012

Free D-amino acids in the tissues of marine bivalves. Felbeck H, Wiley S. Bio Bull. 1987 173:252-259. doi: 10.2307/1541877. PMID: 29315000