Vinnie & Jenna's farewell lunch March 2015
The Dixon lab has recently identified a family of atypical “secreted” kinases that constitute a novel branch within the human kinome tree. The Fam20-family of kinases appears to be responsible for the phosphorylation of extracellular proteins and proteoglycans. What defines these kinases is the presence of a signal peptide that directs these enzymes to the secretory pathway where phosphorylation of ER/Golgi resident proteins, extracellular domains of cell surface receptors, xylose residues within the glycosaminoglycan-protein linkage and secreted proteins occurs.
University of California - San Diego | 9500 Gilman Dr., Leichtag 249, La Jolla, CA 92093, USA